The liver is the body second largest organ after skin. It is responsible for many important functions in the body that ranges from the metabolism of fats, carbohydrates, and proteins to production of clotting factors and detoxification of the toxins, free radicals, and drugs. Any disturbance in the function of the liver can cause liver disease and loss of these functions can cause significant damage to the body.
The circulation of blood works differently in the liver. For example, all the veins in the body transport blood from the peripheral organs to the heart, however, portal vein supplies blood from the heart to the liver for processing and filtering before entering into the general circulation.